By Alison L. Allan
The “cancer stem telephone” speculation postulates that melanoma arises from a subpopulation of tumor-initiating cells or melanoma stem cells (CSCs). whereas the belief of melanoma stem cells has been round for greater than 100 years, proof from the fields of hematology and melanoma biology has now validated the serious function of stem cells in hematological malignancies and instructed that those related mechanisms also are significant to the initiation, development, and remedy of reliable cancers. medical and experimental reports have proven that CSCs show many classical homes of standard stem cells, together with a excessive self-renewal skill and the power to generate heterogeneous lineages; the requirement for a selected “niche”/microenvironment to develop; and an elevated ability for self-protection opposed to harsh environments, pollutants, and medicine.
Cancer Stem Cells in sturdy Tumors represents a close review of melanoma stem cells and their function in sturdy cancers. produced from 24 chapters, this quantity will supply readers with a complete knowing of this crucial and evolving field.
Topics coated include:
- Introduction of the CSC hypothesis
- Historical views and the contributing classes from leukemia
- Current wisdom in regards to the id and position of CSCs in a number of types of strong melanoma together with breast, mind, colorectal, pancreatic, prostate, cancer, lung, ovarian, hepatocellular, and head and neck melanoma
- Molecular pathways excited about using CSC functionality, with a specific concentrate on the radical convergence of embryonic and tumorigenic signaling pathways
- In vitro and in vivo assays, version platforms, and imaging modalities for learning CSCs
- The scientific significance of CSCs for melanoma administration and therapy, together with very important implications for analysis, prediction, and remedy resistance
- Consideration of the talk surrounding the CSC speculation and significant unanswered questions during this field
This collective paintings was once written via a gaggle of in demand overseas specialists in melanoma biology, oncology, and/or stem telephone biology. it's going to function a helpful source for demonstrated researchers, professors, health and wellbeing care pros, and scholars within the scientific and medical neighborhood who're investigating stem cells and/or oncology.
Read or Download Cancer Stem Cells in Solid Tumors (Stem Cell Biology and Regenerative Medicine) PDF
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