Download Human Retrotransposons in Health and Disease by Gael Cristofari PDF

By Gael Cristofari

This detailed ebook explores the position of retrotransposons in human health and disorder. the facility of retrotransposons to impact the constitution of human genes is well-known because the overdue 80’s. despite the fact that, the advances of deep-sequencing applied sciences have shed new mild at the quantity of retrotransposon-mediated genome diversifications. those progresses have additionally resulted in the invention that retrotransposon job isn't constrained to the germline - leading to inheritable genetic adaptations - yet may also mobilize in somatic tissues, similar to embryonic stem cells, neuronal progenitor cells, or in lots of cancers. This ebook covers subject matters on the topic of the results of retrotransposon insertions, and their results on germline and somatic genome dynamics, but additionally talk about the function and impression of retrotransposons sequences in a broader context, together with a few novel issues that emerged lately (long non-coding RNA, neuronal issues, exaptation) with unforeseen connections among retrotransposons, stem mobilephone upkeep, placentation, circadian cycles or aging.

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